The immune system is essential for our health, yet its dysregulation is involved in the pathogenesis of many common diseases. With the concept of an immune sensory system, which integrates the sensingfunctions of immune and non-immune cells, the Cluster of Excellence ImmunoSensation has made several seminal contributions, especially in the field of innate immunity. Our most important findings include the identification of novel receptor ligands, a new second messenger, new paradigms of cell-to-cell communication, a new classification of macrophage activation, insights into immunopathogenesis of cancer, a new target to restore cognitive function, and the impact of Western diet on trained immunity. Furthermore, our basic research has led to two start-up companies, with two compounds in clinical trials in immuno-oncology.
Based on these achievements of the Cluster of Excellence ImmunoSensation, the Bonn Center of Immunology (BCI) was recently founded as an interfaculty center within the Key Profile Area Life and Health of the University of Bonn. The BCI is the main platform for interactions with other local academic institutions, such as the DZNE and caesar. All structural developments of the Cluster of Excellence ImmunoSensation have now been consolidated into the BCI.
Bonn Center of Immunology. The Bonn Center of Immunology is an excellence center for immunology at all levels of structure, education, research and translation. The Bonn Center of Immunology is a joint structure of two faculties of the University of Bonn and the German Center for Degenerative Diseases (DZNE, Helmholtz) and with the MPI-associated center for advanced european studies and research (caesar) contributing outstanding expertise in high-end Imaging and Structural Biology. The core of the Bonn Center of Immunology is the longstanding, well-established collaboration of the Life and Medical Science (LIMES) Institute of the Faculty of Mathematics and Natural Sciences with the groups at the Institutes of Immunosciences and Infection (I3) of the Medical Faculty and the DZNE.